Protein Details: Two pore calcium channel protein 1
Protein ID
ICDB_Pro_1686
Protein Name
Two pore calcium channel protein 1
Gene Name
Tpcn1; Tpc1
Organism
Rattus norvegicus (Rat)
Length
817 amino acids
AlphaFoldDB
AF-Q9WTN5-F1-model_v4.pdb
Function
Intracellular channel initially characterized as a non-selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate); it is also a voltage-gated highly-selective Na(+) channel activated directly by PI(3;5)P2 (phosphatidylinositol 3;5-bisphosphate) that senses pH changes and confers electrical excitability to organelles. Localizes to the early and recycling endosomes membranes where it plays a role in the uptake and processing of proteins and regulates organellar membrane excitability; membrane trafficking and pH homeostasis. Ion selectivity is not fixed but rather agonist-dependent and under defined ionic conditions; can be readily activated by both NAADP and PI(3;5)P2. Required for mTOR-dependent nutrient sensing.
Sequence
PDB Structures
Ligand Binding
Binding Site
Disease
Location
Widely expressed. Expressed at relatively high level in kidney; liver and lung; and in the kidney it is expressed at inner medullary collecting ducts. . . .
DOI ID
10.1006/bbrc.2000.2435; 10.1101/gr.2596504
RefSeq
NP_647548.2;